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Repaglinide/Metformin

Pronunciation: re-PAG-li-nide/met-FOR-min
Generic Name: Repaglinide/Metformin
Brand Name: PrandiMet

Repaglinide/Metformin may rarely cause a serious and sometimes fatal condition called lactic acidosis. Most of these cases have occurred in diabetic patients who also have certain kidney problems. The risk of lactic acidosis may be greater if you have liver problems, kidney problems, or heart failure. The risk may also be greater in patients who are elderly or drink alcohol. Lab tests, including kidney function, may be performed while you take Repaglinide/Metformin.

Do not begin to take Repaglinide/Metformin if you are older than 80 years old unless lab tests show that you do not have decreased kidney function. Do not take it if you have a severe infection, have low blood oxygen levels, or are dehydrated. Tell your doctor you take Repaglinide/Metformin before you have any surgery or lab procedures.

Contact your doctor right away if you notice symptoms such as muscle pain or tenderness; unusual drowsiness, dizziness, or lightheadedness; slow or irregular heartbeat; fast or difficult breathing; unusual stomach discomfort; or unusual weakness or tiredness. Contact your doctor right away if you start to feel unusually cold, or if you have a general feeling of being unwell.

Repaglinide/Metformin is used for:

Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

Repaglinide/Metformin is a meglitinide and biguanide combination. It works by decreasing the amount of sugar absorbed from food by the intestines and reduces the amount of sugar made in the liver. It also increases the amount of insulin in the blood and helps your body to use insulin and sugar more efficiently. This helps to control blood sugar levels.

Do NOT use Repaglinide/Metformin if:

• you are allergic to any ingredient in Repaglinide/Metformin


• you have congestive heart failure that is treated by medicine


• you have a severe infection, low blood oxygen levels, kidney or liver problems, high blood ketone or acid levels (eg, diabetic ketoacidosis), or severe dehydration


• you have had a stroke or a recent heart attack, or you are in shock


• you are 80 years old or older and have not had a kidney function test


• you will be having surgery or certain lab procedures


• you are taking gemfibrozil, gemfibrozil along with itraconazole, or NPH insulin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Repaglinide/Metformin:

Some medical conditions may interact with Repaglinide/Metformin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of heart problems (eg, heart failure), lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, or lactic acidosis


• if you have diarrhea, poor health or nutrition, low blood calcium or vitamin B₁₂ levels, or anemia, or if you are dehydrated or vomiting


• if you have an infection, fever, recent injury, or moderate to severe burns


• if you drink alcohol or have a history of alcohol abuse


• if you will be having surgery or certain lab procedures


• if you take a beta-blocker (eg, propranolol) or are using insulin

Some MEDICINES MAY INTERACT with Repaglinide/Metformin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• NPH insulin because the risk of certain heart problems (eg, myocardial ischemia, chest pain) may be increased


• Amiloride, cimetidine, digoxin, gemfibrozil, imidazoles (eg, ketoconazole), macrolides (eg, erythromycin), morphine, procainamide, quinidine, quinine, ranitidine, rofecoxib, telithromycin, triamterene, trimethoprim, or vancomycin because they may increase the risk of Repaglinide/Metformin's side effects


• Beta-blockers (eg, propranolol), calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), cyclosporine, diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), insulin, isoniazid, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nicotinic acid, phenothiazine (eg, chlorpromazine), phenytoin, salicylates (eg, aspirin), sulfonylureas (eg, glipizide), sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high or low blood sugar may be increased


• Rifampin because it may decrease Repaglinide/Metformin's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Repaglinide/Metformin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Repaglinide/Metformin:

Use Repaglinide/Metformin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Repaglinide/Metformin. Talk to your pharmacist if you have questions about this information.


• Take Repaglinide/Metformin by mouth at least 15 to 30 minutes before each meal. If you skip a meal, do not take the dose for the skipped meal.


• Take Repaglinide/Metformin on a regular schedule to get the most benefit from it. Taking Repaglinide/Metformin at the same time each day will help you remember to take it.


• Continue to take Repaglinide/Metformin even if you feel well. Do not miss any doses.


• If you miss a dose of Repaglinide/Metformin, skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Repaglinide/Metformin.

Important safety information:

• Dizziness may occur while you are taking Repaglinide/Metformin. This effect may be worse if you take it with alcohol or certain medicines. Use Repaglinide/Metformin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Follow the diet and exercise program given to you by your health care provider.


• Do not drink large amounts of alcohol while you use Repaglinide/Metformin. Talk to your doctor or health care provider before you drink alcohol while you use Repaglinide/Metformin.


• Tell your doctor or dentist that you take Repaglinide/Metformin before you receive any medical or dental care, emergency care, or surgery.


• Be careful not to become dehydrated, especially during hot weather or while you are being active. Dehydration may increase the risk of Repaglinide/Metformin's side effects.


• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.


• Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Repaglinide/Metformin exactly as prescribed, tell your doctor.


• Repaglinide/Metformin may cause low blood sugar. Low blood sugar may be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. It may also be more likely if you take Repaglinide/Metformin along with certain medicines for diabetes (eg, sulfonylureas, insulin). It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.


• Fever, infection, injury, or surgery may increase your risk for high or low blood sugar levels. If any of these occur, check your blood sugar closely and tell your doctor right away.


• Repaglinide/Metformin may commonly cause stomach upset, indigestion, nausea, vomiting, or diarrhea at the beginning of treatment. If you develop unusual or unexpected stomach problems, or if you develop stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis.


• Lab tests, including kidney function, fasting blood glucose, hemoglobin A_1c, and blood counts, may be performed while you use Repaglinide/Metformin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Repaglinide/Metformin with caution in the ELDERLY; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly.


• Repaglinide/Metformin should not be used in CHILDREN; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Repaglinide/Metformin while you are pregnant. Repaglinide/Metformin is found in breast milk. Do not breast-feed while taking Repaglinide/Metformin.

When used for long periods of time, Repaglinide/Metformin may not work as well. If your blood sugar has been under control and then becomes hard to manage, contact your doctor. Do not change the dose of your medicine without checking with your doctor.

Possible side effects of Repaglinide/Metformin:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; gas; headache; indigestion; nausea; stomach upset; temporary metallic taste; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; dark urine; dizziness or lightheadedness; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling of being unwell; muscle pain or weakness; slow or irregular heartbeat; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness or lightheadedness; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or tenderness; slow or irregular heartbeat; unusual drowsiness; unusual stomach discomfort; unusual weakness or tiredness.

Proper storage of Repaglinide/Metformin:

Store Repaglinide/Metformin at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Repaglinide/Metformin out of the reach of children and away from pets.

General information:

• If you have any questions about Repaglinide/Metformin, please talk with your doctor, pharmacist, or other health care provider.


• Repaglinide/Metformin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Repaglinide/Metformin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Repaglinide/Metformin resources

• Repaglinide/Metformin Dosage
• Repaglinide/Metformin Use in Pregnancy & Breastfeeding
• Repaglinide/Metformin Drug Interactions
• Repaglinide/Metformin Support Group
• 0 Reviews for Repaglinide/Metformin - Add your own review/rating

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